Phosphodiester models for cleavage of nucleic acids

• Satu Mikkola,
• Tuomas Lönnberg and
• Harri Lönnberg

Beilstein J. Org. Chem. 2018, 14, 803–837, doi:10.3762/bjoc.14.68

• artificial cleaving agents that have enzyme-like catalytic properties but are more robust. pH-Rate profiles, linear free energy relationships and kinetic heavy atom isotope effects are the experimental approaches that are, together with construction of multifunctional cleaving agents, most extensively used

• obtained [29][32]. Linear free energy relationships are, in turn, used to determine the position of transition state on the reaction coordinate [33]. The polar property of either entering or departing nucleophile or non-departing groups is altered in a systematic manner and the effect on reaction rate is

On the mechanism of action of gated molecular baskets: The synchronicity of the revolving motion of gates and in/out trafficking of guests

• Keith Hermann,
• Stephen Rieth,
• Hashem A. Taha,
• Bao-Yu Wang,
• Christopher M. Hadad and
• Jovica D. Badjić

Beilstein J. Org. Chem. 2012, 8, 90–99, doi:10.3762/bjoc.8.9

• the basket: Specifically, the greater the affinity of the guest for occupying the basket, the less effective the gates are in “sweeping” the guest as the gates undergo their revolving motion. Keywords: dynamic NMR; host–guest chemistry; linear free-energy relationships; molecular encapsulation

Equilibrium constants and protonation site for N-methylbenzenesulfonamides

• José A. Moreira,
• Ana M. Rosa da Costa,
• Luis García-Río and
• Márcia Pessêgo

Beilstein J. Org. Chem. 2011, 7, 1732–1738, doi:10.3762/bjoc.7.203

• parameter than with σ, which indicates that the initial protonation site is the oxygen atom of the sulfonyl group. Keywords: linear free-energy relationships; N-methylbenzenesulfonamides; protonation equilibrium; Introduction Having a knowledge of the protonation equilibrium constants for N

Alkene selenenylation: A comprehensive analysis of relative reactivities, stereochemistry and asymmetric induction, and their comparisons with sulfenylation

• Vadim A. Soloshonok and
• Donna J. Nelson

Beilstein J. Org. Chem. 2011, 7, 744–758, doi:10.3762/bjoc.7.85

• magnitude greater (Table 1, entries 20 versus 21, or 26 versus 27). 3. Alkyl branching α to C=C: The data obtained in this study pointed to a new steric effect in linear free energy relationships, which can be defined as alkyl group α-branching. Thus, within each line fit, there is a clear trend dependent